Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia
نویسندگان
چکیده
منابع مشابه
Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia.
OBJECTIVE To characterize and quantify the patterns of temporal lobe atrophy in AD vs semantic dementia and to relate the findings to the cognitive profiles. Medial temporal lobe atrophy is well described in AD. In temporal variant frontotemporal dementia (semantic dementia), clinical studies suggest polar and inferolateral temporal atrophy with hippocampal sparing, but quantification is largel...
متن کاملPatterns of brain atrophy in frontotemporal dementia and semantic dementia.
OBJECTIVE To identify and compare the patterns of cerebral atrophy associated with two clinical variants of frontotemporal lobar degeneration (FTLD): frontotemporal dementia (FTD) and semantic dementia (SemD). METHODS Twenty patients with FTLD were classified as having FTD (N = 8) or SemD (N = 12) based on current clinical criteria. Both groups showed a similar spectrum of behavioral abnormal...
متن کاملSemantic dementia. Progressive fluent aphasia with temporal lobe atrophy.
We report five patients with a stereotyped clinical syndrome characterized by fluent dysphasia with severe anomia, reduced vocabulary and prominent impairment of single-word comprehension, progressing to a stage of virtually complete dissolution of the semantic components of language. A marked reduction in the ability to generate exemplars from restricted semantic categories (e.g. animals, vehi...
متن کاملA voxel-based morphometry study of semantic dementia: relationship between temporal lobe atrophy and semantic memory.
The cortical anatomy of 6 patients with semantic dementia (the temporal lobe variant of frontotemporal dementia) was contrasted with that of a group of age-matched normal subjects by using voxel-based morphometry, a technique that identifies changes in gray matter volume on a voxel-by-voxel basis. Among the circumscribed regions of neuronal loss, the left temporal pole (Brodmann area 38) was th...
متن کاملCinguloparietal atrophy distinguishes Alzheimer disease from semantic dementia.
BACKGROUND Progressive brain atrophy is associated with Alzheimer disease (AD) and other dementias. Regional differences in brain atrophy may reflect clinical features of disease. OBJECTIVE To identify regions of cerebral atrophy that are associated with AD vs other dementias. SETTING University hospital dementia clinic. PARTICIPANTS Eleven patients with AD and 11 with semantic dementia (...
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ژورنال
عنوان ژورنال: Neurology
سال: 2001
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.57.2.216